DOI: 10.22184/1993-7296.FRos.2020.14.6.510.519

The first part of this research deals with development of a method for the laser formation of a biocompatible surface morphology of titanium dental implants, providing a hydrophilic surface structure that has both micro- and nanorelief. In this second part of the study, we present the results of preclinical tests of the laser-­induced relief’s biocompatibility. The implants with the modified surface showed an advanced proliferation of multipotent mesenchymal stromal cells over the entire surface area, even in open pores. Implants with such a surface also showed positive results of osseointegration in a living organism: three months after implantation, a new mature bone tissue is formed in the previously destroyed bone area, which is directly connected to the implant surface. The technology based on this method has been adopted into the production of a dental milling center for a full production cycle and a plant belonging to the ORTOS group of companies.


Разработка: студия Green Art